Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in hyperexcitability during status epilepticus
Together, these results show that the synaptic accumulation of GluN2B-containing NMDA receptors mediate the effects of BDNF in the plasticity of glutamatergic synapses in the hippocampus.
Authors
- Carlos B. Duarte (ORCID: https://orcid.org/0000-0002-1474-0208)
- Ana M. Sebastião (ORCID: https://orcid.org/0000-0001-9030-6115)
- Maria José Diógenes (ORCID: https://orcid.org/0000-0001-5486-6246)
- Alexander Schwarz (ORCID: https://orcid.org/0000-0003-2707-1397)
- Sara R. Tanqueiro (ORCID: https://orcid.org/0000-0002-9151-7149)
- Miranda Mele (ORCID: https://orcid.org/0000-0002-8627-4883)
- Meinrad Drexel (ORCID: https://orcid.org/0000-0002-2705-9673)
- Pasqualino De Luca (ORCID: https://orcid.org/0000-0002-1113-2135)
- Arthur Cardoso Souto
- Rui O. Costa (ORCID: https://orcid.org/0000-0002-2652-7500)
- Francesca Napoli (ORCID: https://orcid.org/0009-0009-3570-3826)
- Ugné Butkevičiūtė
Institutions
- University of Lisbon (PT)
- Innsbruck Medical University (AT)
- Institute of Evolutionary Physiology and Biochemistry (RU)
- Universität Innsbruck (AT)
- University of Coimbra (PT)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12929-025-01164-4
- Citations
- 5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- Programa Operacional Regional do Centro
- Fundação para a Ciência e a Tecnologia
- European Regional Development Fund