Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach

Genes related to the immunological function of NK cells, especially the NK cell receptor and co-activating receptor genes, were significantly dysregulated in the severe patient group in both cytokine and single-cell levels. Collectively, mutation hotspots associated with severity and their related NK cell associated gene expression regulation were identified.

Authors

Inuk Jung (ORCID: https://orcid.org/0000-0003-0675-4244)
Dabin Jeong (ORCID: https://orcid.org/0000-0001-9910-8051)
Hee Young Kwon (ORCID: https://orcid.org/0000-0002-8158-4110)
Sohyun Youn
Eung Soo Han (ORCID: https://orcid.org/0000-0001-9459-1275)
Sun Kim (ORCID: https://orcid.org/0000-0001-5385-9546)

Institutions

Seoul National University (KR)
Wellcome Sanger Institute (GB)
Kyungpook National University (KR)
Institute of Refrigeration (GB)

Publication Details

Journal: BioData Mining
Published: 2025-09-01
DOI: https://doi.org/10.1186/s13040-025-00476-3
Primary Topic: SARS-CoV-2 and COVID-19 Research
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Korea Disease Control and Prevention Agency
Korea National Institute of Health

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article

Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach

Inuk Jung, Dabin Jeong, Hee Young Kwon, Sohyun Youn et al.

Sep 1, 2025

BioData Mining

SARS-CoV-2 and COVID-19 Research

article

Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach

Inuk Jung, Dabin Jeong, Hee Young Kwon, Sohyun Youn, Eung Soo Han, Sun Kim

September 1, 2025article en

Abstract

Genes related to the immunological function of NK cells, especially the NK cell receptor and co-activating receptor genes, were significantly dysregulated in the severe patient group in both cytokine and single-cell levels. Collectively, mutation hotspots associated with severity and their related NK cell associated gene expression regulation were identified.

BioData MiningVol. 18(1)

Seoul National University (KR), Wellcome Sanger Institute (GB), Kyungpook National University (KR), Institute of Refrigeration (GB)

Korea Disease Control and Prevention Agency, Korea National Institute of Health

Openalex Percentile: Top 72%

SARS-CoV-2 and COVID-19 Research

DOI Open Access PDF OpenAlex

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Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach — Inuk Jung, Dabin Jeong, et al. · BioData Mining (2025) | TGRS Research Map | TGRS