Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain
These findings provide robust preclinical evidence that co-administration of pregabalin and thioctic acid produces synergistic antiallodynic effects in a validated model of neuropathic pain. This interaction enables effective analgesia at reduced doses, supporting a potential tolerability advantage. Our data support further investigation of this combination in chronic dosing paradigms, inclusion of both sexes, and clinical translation.
Authors
- Eduardo Zárate
- Vinicio Granados‐Soto (ORCID: https://orcid.org/0000-0003-1038-8400)
- Óscar Arias-Carrión (ORCID: https://orcid.org/0000-0002-9982-7571)
Institutions
- MSD (Mexico) (MX)
- Instituto Nacional de Rehabilitación (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fphar.2025.1675015
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Institute of Nuclear Energy Research
- H2020 European Research Council