Characterization of Chronic Rhinosinusitis Patients Based on Markers of Type 2 Inflammation: Findings From the European CRS Outcome Registry (CHRINOSOR)
A significant proportion of CRS patients exhibit a type 2 endotype, characterized by blood eosinophilia (78%), increased serum total IgE (40%) and/or concomitant asthma (59%). Our results underline the usefulness of eosinophils as a marker of type 2 inflammation and severity but challenge the utility of serum total IgE since it does not correlate with any of the markers of severity.
Authors
- Antonella Loperfido (ORCID: https://orcid.org/0000-0002-7174-8126)
- Laura Van Gerven (ORCID: https://orcid.org/0000-0002-5325-7956)
- Anu Laulajainen‐Hongisto (ORCID: https://orcid.org/0000-0001-5109-6944)
- Wytske J. Fokkens (ORCID: https://orcid.org/0000-0003-4852-229X)
- Sven Seys (ORCID: https://orcid.org/0000-0002-4399-9892)
- Peter W. Hellings (ORCID: https://orcid.org/0000-0001-6898-688X)
- Valerie J. Lund (ORCID: https://orcid.org/0000-0002-2503-2215)
- Kenneth H. Larsen
- Martin Wagenmann (ORCID: https://orcid.org/0000-0002-9734-0241)
- Zuzana Diamant (ORCID: https://orcid.org/0000-0003-0133-0100)
- Simonetta Masieri (ORCID: https://orcid.org/0000-0003-0423-9505)
- Peter Valentin Tomazic (ORCID: https://orcid.org/0000-0001-6445-4800)
- Clemens Holzmeister (ORCID: https://orcid.org/0000-0003-2835-5121)
- Sietze Reitsma (ORCID: https://orcid.org/0000-0003-1734-2632)
- Anette Drøhse Kjeldsen (ORCID: https://orcid.org/0000-0003-0593-6302)
- Carlo Cavaliere (ORCID: https://orcid.org/0000-0002-0378-8935)
- G. Mortuaire (ORCID: https://orcid.org/0000-0002-1592-1625)
- Julia Eckl‐Dorna (ORCID: https://orcid.org/0000-0001-5981-1607)
- Joaquim Mullol (ORCID: https://orcid.org/0000-0003-3463-5007)
- Claire Hopkins (ORCID: https://orcid.org/0000-0003-3993-1569)
- Sven Schneider (ORCID: https://orcid.org/0000-0002-7631-3746)
- Mathilde Moyaert (ORCID: https://orcid.org/0009-0002-5412-1484)
- Josje Otten (ORCID: https://orcid.org/0009-0003-5437-3005)
- Alexandros Andrianakis (ORCID: https://orcid.org/0000-0002-2530-9931)
- Isam Alobid (ORCID: https://orcid.org/0000-0003-2557-6017)
- Gert Mariën
- Claus Bachert
- Valérie Hox (ORCID: https://orcid.org/0000-0003-2390-294X)
- Giulia Bettio
- Joost de Kinderen
- Camilo Rodriquez‐Van Strahlen
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University Medical Center Groningen (NL)
- University of Helsinki (FI)
- Sun Yat-sen University (CN)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Medical University of Graz (AT)
- Charles University (CZ)
- University of Münster (DE)
- Universitair Ziekenhuis Leuven (BE)
- Helsinki University Hospital (FI)
- Odense University Hospital (DK)
- Vienna General Hospital (AT)
- Centre Hospitalier Universitaire de Lille (FR)
- Düsseldorf University Hospital (DE)
- University Hospital Münster (DE)
- Hospital Clínic de Barcelona (ES)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Royal National Throat Nose and Ear Hospital (GB)
- Thomayer University Hospital (CZ)
- Amsterdam University Medical Centers (NL)
- Carlo Forlanini Hospital (IT)
- Hôpital Claude Huriez (FR)
- Heinrich Heine University Düsseldorf (DE)
- Universitat de Barcelona (ES)
- Medical University of Vienna (AT)
- Sapienza University of Rome (IT)
- University of Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1002/clt2.70095
- Citations
- 3
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- GlaxoSmithKline
- Sanofi
- Regeneron Pharmaceuticals
- Novartis Pharma