Optimizing short-term antibiotic treatment in patients with acute cholangitis: study protocol for an open-label randomized controlled trial (the BOLT-P3 trial)
This phase 3 trial aims to determine the non-inferiority of short-course therapy over standard-course therapy. Shortening the duration of antibiotic administration may mitigate the emergence of resistant bacteria, adverse events, and reduce hospital stay length and healthcare costs. https://jrct.niph.go.jp/re/reports/detail/73862 TRIAL REGISTRATION: This study was registered at the Japan Registry of Clinical Trials under registry number jRCT1031230709. Registered on 14 March 2024, https://jrct.niph.go.jp/re/reports/detail/73862.
Authors
- Aya Kawanishi
- Hiroshi Takihara
- Yoshinori Imamura (ORCID: https://orcid.org/0000-0002-5202-531X)
- Tomoaki Fujikawa (ORCID: https://orcid.org/0000-0001-7734-546X)
- Kyohei Maejima
- Kazuya Koizumi (ORCID: https://orcid.org/0000-0002-3677-5030)
- Ryuhei Jinushi (ORCID: https://orcid.org/0000-0002-0422-6723)
- Satoru Noda
- Jun Kubota (ORCID: https://orcid.org/0000-0002-1891-4746)
- Taiji Koyama (ORCID: https://orcid.org/0000-0002-2893-605X)
- Karen Kimura
- Ayumu Sugitani (ORCID: https://orcid.org/0000-0002-6634-0636)
- Shomei Ryozawa (ORCID: https://orcid.org/0000-0003-4128-9990)
- Makomo Makazu (ORCID: https://orcid.org/0000-0002-9130-651X)
- Sakue Masuda (ORCID: https://orcid.org/0000-0002-9868-162X)
- Ryuichi Yamamoto (ORCID: https://orcid.org/0000-0003-0299-5470)
Institutions
- Tokai University (JP)
- Shonan Institute of Technology (JP)
- Fujisawa City Hospital (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
- San-ikukai Hospital (JP)
- Fukuoka Tokushukai Hospital (JP)
- University of Fukui Hospital (JP)
- Chiba-Nishi General Hospital (JP)
- Uji Hospital (JP)
- Saitama International Medical Center (JP)
- Shonan Kamakura General Hospital (JP)
- Kobe University (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Trials
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13063-025-09077-1
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Research Foundation for Clinical Pharmacology