The predictive validity of pontine volume change in spinocerebellar ataxia type 1 (SCA1)
This study confirms high responsiveness of pontine volume loss and provides first evidence of its predictive validity, as one-year changes in pontine volume were associated with subsequent changes in ataxia severity and gait. Pontine volume loss is thus a candidate surrogate endpoint in SCA1 clinical trials.
Authors
- Jack J.A. van Asten (ORCID: https://orcid.org/0000-0002-2135-5682)
- Marcel M. Verbeek (ORCID: https://orcid.org/0000-0003-4635-7876)
- Bart P.C. van de Warrenburg (ORCID: https://orcid.org/0000-0003-4412-1616)
- Tom W. J. Scheenen (ORCID: https://orcid.org/0000-0002-4468-1480)
- Teije van Prooije (ORCID: https://orcid.org/0000-0002-6372-0801)
- Kirsten Kapteijns (ORCID: https://orcid.org/0000-0001-5735-1934)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.nbd.2025.107078
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- ZonMw