To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network
Retrograde activation times increased and the duration of reentrant arrhythmias shortened in the absence of Purkinje fiber reconnections in the Purkinje fiber network. This could be an important structural HPS property to incorporate into computational heart models when investigating retrograde activation and/or reentrant arrhythmias. Modifying the structure of the Purkinje fiber network to remove Purkinje fiber reconnections in patients with life threatening ventricular arrhythmia might be antiarrhythmic.
Authors
- Gernot Plank (ORCID: https://orcid.org/0000-0002-7380-6908)
- Karli Gillette (ORCID: https://orcid.org/0000-0002-0420-5375)
- Ruben Coronel (ORCID: https://orcid.org/0000-0001-9433-6119)
- Edward J. Vigmond (ORCID: https://orcid.org/0000-0003-1388-3589)
- Jason D. Bayer (ORCID: https://orcid.org/0000-0003-0269-3499)
Institutions
- Université de Bordeaux (FR)
- Medical University of Graz (AT)
- University of Utah (US)
- Electrophysiology and Heart Modeling Institute (FR)
- Amsterdam University Medical Centers (NL)
- Institut de Mathématiques de Bordeaux (FR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fphys.2025.1657611
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Agence Nationale de la Recherche
- Austrian Science Fund
- Grand Équipement National De Calcul Intensif