A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation
TLS-related prognostic signatures serve as effective tools for predicting CRC outcomes. Moreover, intratumorally TLS may enhance the prognosis of patients with BRAF<sup>MT</sup> CRC, highlighting its potential as a therapeutic and prognostic biomarker. Colorectal cancer, <i>BRAF</i> mutation, tertiary lymphoid structures, tumor microenvironment, prognosis.
Authors
- Yun Leng (ORCID: https://orcid.org/0000-0003-2907-3599)
- Ke Zhu (ORCID: https://orcid.org/0000-0002-3504-1262)
- Bihui Huang (ORCID: https://orcid.org/0000-0003-3084-7096)
- Linlin Hou (ORCID: https://orcid.org/0000-0002-7796-7346)
- W. Li (ORCID: https://orcid.org/0009-0005-9617-472X)
- Lei Wang (ORCID: https://orcid.org/0000-0003-2402-2338)
- Shihua Li (ORCID: https://orcid.org/0000-0001-9044-7137)
- Chao Qin (ORCID: https://orcid.org/0000-0002-1741-4790)
- Jingyun Ma
- Huiying Chen (ORCID: https://orcid.org/0000-0001-8783-251X)
- Hui Mo (ORCID: https://orcid.org/0000-0001-5415-2788)
- Shumin Cheng (ORCID: https://orcid.org/0000-0002-4627-8791)
- Jing Liang (ORCID: https://orcid.org/0000-0002-3019-6847)
- Lei Zheng (ORCID: https://orcid.org/0009-0001-7405-3880)
- Yuhong Liang
- Lujing Li
- Yuxuan Liu (ORCID: https://orcid.org/0009-0008-6732-7717)
- Yu Zhang (ORCID: https://orcid.org/0009-0005-6052-7087)
Institutions
- Macau University of Science and Technology (MO)
- Sun Yat-sen University (CN)
- University of Macau (MO)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1662573
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Spinal Muscular Atrophy Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province