Expression of cyclooxygenase-2 and smooth muscle actin biomarkers in different subtypes of basal cell carcinoma

COX-2 expression significantly correlated with tumor invasion depth and recurrence in BCC, highlighting its potential as a prognostic marker and therapeutic target, while SMA showed limited relevance to tumor behavior. Although excision margin size did not show a statistically significant correlation with recurrence (<i>p</i> = 0.371), tumors with margins >0.5 cm exhibited a lower recurrence rate (11.4%), suggesting a possible impact on treatment outcomes.