Integrated transcriptomic analysis identifies lactylation-linked gemcitabine resistance and therapeutic targets in intrahepatic cholangiocarcinoma
This study sheds light on the molecular mechanisms of gemcitabine resistance in iCCA, emphasizing lactylation's role and the significance of immune modulation. ITGB4 is identified as a promising therapeutic target, and the findings suggest that targeting these genes could help overcome resistance in iCCA.
Authors
- Wenwei Xie (ORCID: https://orcid.org/0000-0002-5253-4245)
- Jialiang Hu (ORCID: https://orcid.org/0000-0002-6630-1514)
- Hanmei Xu (ORCID: https://orcid.org/0000-0002-8942-0794)
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fcell.2025.1611434
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China