Integrative network pharmacology, metabolomics and gut flora studies reveal mechanisms of action of Rhododendron molle (Blume) G. Don to ameliorate liver injury
RML has the potential to enhance the composition of intestinal microbiota by through the differential regulation of various metabolized components, including 13-OxoODE, morphine, and niacinamide, it influences several metabolic pathways, notably steroid biosynthesis, lysine degradation, interconversions of pentose and glucuronate, as well as the metabolism of linoleic acid. Additionally, it may promote the proliferation of <i>HT002</i> and <i>Lactobacillus</i> probiotics, thereby contributing to the amelioration of LI. It establishes a robust foundation for future applications and the development of associated pharmaceuticals.
Authors
- Tianwei Meng (ORCID: https://orcid.org/0000-0001-8311-6903)
- Hong Chang (ORCID: https://orcid.org/0000-0002-2668-0070)
- Yan Zhuang (ORCID: https://orcid.org/0000-0003-0419-3615)
- Xinghua Li (ORCID: https://orcid.org/0000-0003-2156-5775)
- Xiaolei Jiang
- Tiancheng Meng
- Hongyu Meng
- Dan He (ORCID: https://orcid.org/0000-0003-1845-0379)
Institutions
- Beijing University of Chinese Medicine (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Changzhi Medical College (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fmicb.2025.1570229
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- Baotou Medical College