Profiling bile acid composition in bile from mice of different ages and sexes
The findings demonstrate that bile BA profiles differ markedly with both sex and physiological age in commonly used normal laboratory mice, suggesting the need to consider for physiological differences related to sex and age when selecting suitable animals for pharmaceutical research and for mechanistic studies.
Authors
- Jiajian Liu (ORCID: https://orcid.org/0000-0001-8148-6791)
- Kun Ge (ORCID: https://orcid.org/0000-0001-8972-837X)
- Chun Qu (ORCID: https://orcid.org/0000-0003-3657-2978)
- Qing Zhao (ORCID: https://orcid.org/0000-0003-3437-533X)
- Wei Jia (ORCID: https://orcid.org/0000-0002-3739-8994)
- Li Yang (ORCID: https://orcid.org/0000-0002-5484-0895)
- Aihua Zhao (ORCID: https://orcid.org/0000-0003-0201-3940)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fphys.2025.1626215
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Shanghai Jiao Tong University