Housekeeping gene dysregulation in psoriasis: integrative multi‐cohort and single‐cell analysis reveals keratinocyte‐centric molecular mechanisms and diagnostic biomarkers
This study redefines housekeeping genes as dual-function regulators in psoriasis pathogenesis, with the avNNet model enabling clinical translation of these molecular insights toward precision-targeted therapies and biomarker-based management strategies.
Authors
- Xiangshu Cheng
- Xin Meng (ORCID: https://orcid.org/0000-0002-7071-2842)
- Yongshuai Jiang (ORCID: https://orcid.org/0000-0002-7163-6554)
- Wenhua Lv (ORCID: https://orcid.org/0000-0002-2528-4754)
- Guang-Long Feng
- Ruijie Zhang (ORCID: https://orcid.org/0000-0003-0778-3194)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0002-8523-3975)
- Rui Chen (ORCID: https://orcid.org/0000-0002-7708-3962)
- Hao Tang (ORCID: https://orcid.org/0000-0003-2202-0515)
- Shuhao Zhang (ORCID: https://orcid.org/0000-0002-0301-5983)
- Jiacheng Wang (ORCID: https://orcid.org/0009-0004-3270-0252)
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1601705
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China