Apparent diffusion coefficient predicts MGMT status in adult-type diffuse gliomas and is correlated with Ki-67 proliferation index

ADC values, particularly rADCmin, were identified as non-invasive biomarkers for MGMT methylation prediction in IDH-wild-type gliomas. An inverse correlation between ADC and Ki-67 index supported their utility for assessing tumor proliferation. Standardizing rADC would improve its clinical applicability across imaging platforms.