Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head
We have delineated the cellular heterogeneity and molecular signatures of cystic lesions in SIONFH. The results reveal a distinct repair program within these lesions, which might be driven by chondrocyte hypertrophy and might culminate in osteogenic differentiation.
Authors
- Shun Lü (ORCID: https://orcid.org/0000-0001-8833-7262)
- Fangjun Xiao (ORCID: https://orcid.org/0000-0002-3945-5526)
- Mincong He (ORCID: https://orcid.org/0000-0002-6849-3679)
- Xiaoqiang Yang (ORCID: https://orcid.org/0000-0002-0820-1291)
- Wei He (ORCID: https://orcid.org/0000-0002-2755-9504)
- Wenyuan Hou (ORCID: https://orcid.org/0000-0003-1436-6903)
- Huan Xiao (ORCID: https://orcid.org/0000-0003-0612-797X)
- Qiushi Wei (ORCID: https://orcid.org/0000-0002-1274-9997)
- Peng Peng (ORCID: https://orcid.org/0009-0002-7993-8001)
- Weihua Fang (ORCID: https://orcid.org/0000-0002-5621-6535)
- Kun Lin (ORCID: https://orcid.org/0000-0003-1243-030X)
- Fangming Yao
- Jiaqing Tian
Institutions
- Guangzhou University of Chinese Medicine (CN)
- IE University (ES)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1626337
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00