ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF A NEW PHARMACEUTICAL COMPOSITION IN THE FORM OF TABLETS BASED ON DRY EXTRACT OF AIR LEAVES AND QUERCETIN

Background. Gastrointestinal tract diseases are one of the most common pathologies in the world. According to modern statistics, more than 40% of the world's population suffers from certain diseases of the digestive system. Among them, the most common are gastritis, NSAID gastropathies, and gastric ulcers. Modern pharmacotherapy of inflammatory and destructive diseases of the stomach includes a wide range of highly effective synthetic drugs, but their use is often accompanied by side effects. In this regard, the search for new effective, safe and affordable drugs remains an urgent task of modern pharmacy. Rhizomes of sweet flag (Acorus calamus) have long been used in traditional and folk medicine for the treatment of gastrointestinal diseases. In the context of a modern approach to the rational use of natural resources, scientific interest in other parts of the plant is growing, in particular leaves, which are not inferior in chemical composition to rhizomes. Aim. To investigate the anti-inflammatory and antioxidant properties of a new pharmaceutical composition in the form of tablets based on dry extract of calamus leaves and quercetin in models of aspirin and alcohol-prednisolone gastric damage. Materials and methods. The study was conducted on experimental models of aspirin and alcohol-prednisolone gastric damage in rats. The anti-inflammatory and antioxidant properties of the new pharmaceutical composition in the form of tablets based on dry extract of Acorus calamus leaves and quercetin were determined by biochemical blood parameters - total and C-reactive protein, inflammatory and anti-inflammatory cytokines - interleukin 6 and 10, prostaglandin E2, catalase, superoxide dismutase, thiobarbituric acid reactants. Results. According to the results of the study, it was found that the use of a new pharmaceutical composition in the form of tablets based on dry extract of calamus leaves and quercetin normalizes inflammation indicators - C-reactive protein, prostaglandin E2, interleukin-6, anti-inflammatory interleukin 10, lipid peroxidation - TBA reactants, antioxidant protection indicators - superoxide dismutase and catalase. Conclusion. 1) A new pharmaceutical composition in the form of tablets based on dry extract of calamus leaves and quercetin exhibits anti-inflammatory and antioxidant effects both in the prophylactic treatment of aspirin-induced gastric damage and in the prophylactic and therapeutic regimen of use in alcohol-prednisolone gastric damage in rats. 2) The anti-inflammatory properties of the new pharmaceutical composition in the form of tablets based on dry extract of calamus leaves and quercetin are associated with a decrease in the levels of pro-inflammatory markers of acute and chronic inflammation - CRP, IL-6, PGE2, and an increase in the level of the anti-inflammatory cytokine IL-10. 3) The pharmaceutical composition in the form of tablets based on dry extract of calamus leaves and quercetin exhibits antioxidant properties by reducing the level of POL products and increasing the amount of catalase and SOD, which belong to the AOP system.