Atg7 in CD4<sup>+</sup> T cells improves intestinal mucosal inflammation by regulating Ets1‐mediated T cell differentiation
Atg7 expression was significantly elevated in the inflamed mucosa and blood CD4<sup>+</sup> T cells of patients with active Crohn's disease. Specific-knockout of Atg7 in CD4<sup>+</sup> T cells leads to exacerbated colitis severity. Ets1 functions as a target of Atg7, where it inhibits Th1 cell differentiation and promotes Treg cell differentiation.
Authors
- Yan Jin (ORCID: https://orcid.org/0000-0001-5957-7443)
- Mingqiu Dai (ORCID: https://orcid.org/0000-0001-6737-8209)
- Fei Xu (ORCID: https://orcid.org/0000-0002-1243-491X)
- Min Ai
- Q. Zhang
- Hai‐Jian Sun (ORCID: https://orcid.org/0000-0002-7791-5335)
- Yuetao Zhou (ORCID: https://orcid.org/0000-0003-1870-3276)
- Shuo Du (ORCID: https://orcid.org/0000-0003-4027-5167)
- Jian Lü (ORCID: https://orcid.org/0000-0002-9144-7486)
- Xin‐Xing Wang
- Hong Chen (ORCID: https://orcid.org/0009-0001-4528-8015)
- Yingwei Zhu (ORCID: https://orcid.org/0009-0001-7865-6806)
- Liying Qiu
- Mei‐Zhen Zhu (ORCID: https://orcid.org/0000-0002-6592-7486)
- Xue‐Xue Zhu (ORCID: https://orcid.org/0009-0003-9847-6882)
- Shuang‐Shuang Li (ORCID: https://orcid.org/0000-0002-1177-7339)
Institutions
- Jiangnan University (CN)
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Wuxi Fourth People's Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Seventh People's Hospital of Shanghai (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1002/ctm2.70462
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province