MEDICAL AND SANITARY STANDARDIZATION OF THE NEW HIGHLY RESISTANT PESTICIDE ISOCYCLOSERAM IN SOIL (FIRST REPORT)

Aim: experimental establishment of the features of vertical migration of isocycloceram - a modern insecticide from the chemical class of isoxazoles from soil into groundwater and atmospheric air for further scientific substantiation of the medical and sanitary standard - the maximum permissible concentration in soil. Materials and methods. Laboratory experiments were conducted to study the behavior of isocycloceram in the “soil - groundwater” and “soil - air” systems and the threshold concentrations of the compound in the soil were justified based on water-migration and air-migration indicators of harmfulness. Results. It is shown that the migration of isocycloceram from soil to adjacent environments depends on the type of soil and the initial concentrations of the substance. In extreme soil and climatic conditions, threshold concentrations of isocycloceram in soil have been established according to water-migration (0.05 mg/kg) and air-migration (more than 1.0 mg/kg) indicators of harmfulness. It has been proven that at concentrations of isocycloceram in soil equal to or lower than 0.05 mg/kg, the levels of migration of the substance into the soil stream will not exceed its maximum inactive concentration (MIC) in water bodies according to the sanitary-toxicological indicator of harmfulness (0.01 mg/dm3), i.e. will not exceed 10% of the permissible daily intake calculated based on the value of the approved permitted daily exposure (PDE), which is equal to 0.005 mg/kg. At isocycloceram concentrations in sandy soil of 1.0 mg/kg and below, the levels of its migration into the air, even at a soil temperature of 70 °C, will not exceed the medical and sanitary standard in atmospheric air (0.0015 mg/m3). Conclusion. The leading of the two studied links of migration of isocycloceram in the environment is the system “soil - groundwater”, since the threshold concentration of the substance in the soil according to the water-migration indicator of harmfulness turned out to be the lowest. The use of insecticidal preparations based on isocycloceram for the protection of agricultural crops with recommended consumption rates and multiplicity of treatments will not cause pollution of groundwater and atmospheric air dangerous to the health of the population in the soil and climatic conditions of Ukraine.