Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice
Taken together, these findings highlight that subacute (14-day) exposure to WS results in persistent neurometabolomic and behavioral alterations in an aged mouse model and that intervention with RNMN may be a useful strategy to mitigate the adverse neurological outcomes observed. Further studies are needed to assess the specific impact of either resveratrol or NMN in isolation and to fully elucidate age-specific, as well as sex- and species-determinant, WS exposure response pathways.
Authors
- Jonathan L. Brigman (ORCID: https://orcid.org/0000-0001-6786-3263)
- Ed Barr
- Haiwei Gu (ORCID: https://orcid.org/0000-0002-7598-5022)
- Guy Herbert
- Kiran Bhaskar (ORCID: https://orcid.org/0000-0001-6064-8106)
- Barry E. Bleske (ORCID: https://orcid.org/0000-0002-4299-0829)
- Jessica Begay
- Matthew J. Campen (ORCID: https://orcid.org/0000-0002-2292-5050)
- Andrew K. Ottens (ORCID: https://orcid.org/0000-0002-2118-3796)
- Amanda M. Barkley‐Levenson (ORCID: https://orcid.org/0000-0003-3722-7578)
- Mark A. McCormick (ORCID: https://orcid.org/0000-0002-4916-8280)
- David Scieszka (ORCID: https://orcid.org/0000-0001-9357-7121)
- Jonathan Hulse (ORCID: https://orcid.org/0000-0001-6184-2058)
- Marcus Garcia
Institutions
- University of New Mexico (US)
- Virginia Commonwealth University (US)
- Arizona State University (US)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12989-025-00639-4
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- National Institutes of Health