Dectin-1-targeted pH-responsive liposomal nanoplatform delivering Plantago Asiatica L. acidic polysaccharide for immunomodulation and immunosuppressive breast cancer microenvironment reprogramming
This study establishes curdlan-modified liposomes as the dual-functional nanoplatform that synergistically enhances DC-targeted delivery of PLP-II and systemic immune activation, providing a promising strategy to augment cancer immunotherapy.
Authors
- Wanbing Pan
- Zhihui Hao (ORCID: https://orcid.org/0000-0001-9516-6270)
- Jinglin Huang
- Yanyan Jiang (ORCID: https://orcid.org/0000-0002-7866-4689)
- Jintong Liu (ORCID: https://orcid.org/0000-0001-5936-7964)
- Can Li (ORCID: https://orcid.org/0000-0002-9301-7850)
- Wei Liu (ORCID: https://orcid.org/0000-0002-8945-6914)
- Qiao Lin (ORCID: https://orcid.org/0000-0002-6040-2867)
- Jiahao Lin (ORCID: https://orcid.org/0000-0003-1244-7339)
- Xiaoyu Zhou (ORCID: https://orcid.org/0000-0001-9911-3088)
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s12951-025-03638-x
- Citations
- 4
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- National Natural Science Foundation of China