LysR-type transcriptional regulator CARR represses the expression of blaCAR-2 and reduces P. diazotrophicus resistance to cefalothin, cefuroxime and cefotaxime
Overall, CAR-2 is a novel subclass B3 MBL of the CAR family that exhibits catalytic activity against cefalothin, cefuroxime and cefotaxime. CARR represses the expression of <i>bla</i> <sub>CAR-2</sub>, thereby reducing the resistance of <i>P. diazotrophicus</i> to these antibiotics. This provided a theoretical basis for revealing new mechanisms of pathogen resistance.
Authors
- Jun Zheng (ORCID: https://orcid.org/0000-0001-6329-4518)
- Chunyan Lin
- Jiansheng Lin
Institutions
- Huaqiao University (CN)
- Quzhou City People's Hospital (CN)
- The 180th Hospital of PLA (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fcimb.2025.1616646
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Quanzhou City Science and Technology Program