Decoding the prenatal clock of sheep muscle fiber type differentiation: a temporal map from embryonic to mature types

This study provides the first integrated multi-omics characterization of muscle fiber type development in late-gestation sheep, identifying D105 as a pivotal transition point in myofiber specification. Our findings reveal coordinated molecular and metabolic changes underlying the transition from embryonic to mature fibre types, with significant implications for understanding ruminant muscle development. These results establish a scientific foundation for improving meat quality through targeted molecular breeding strategies and prenatal nutritional interventions in sheep production systems.