In silico testing of a multimaterial scaffold for mandibular reconstruction

No failure was predicted in the fixation devices for any of the configurations investigated. The PLA fixation device induced higher strains within the healing region than the titanium fixation device. Differences in scaffold architecture did not influence the strain levels within the healing region. Changes in the scaffold material distribution led to considerable differences in the mechanical strains within the scaffold pores. The multimaterial scaffold induced higher strains within the healing region than the only hydrogel scaffold, which might be beneficial to promote bone healing in the defect. Thus, a multimaterial scaffold seems to be able to provide a more suitable biomechanical environment to support bone regeneration, especially in large segmental defects. Future studies should focus on the mechanobiological optimization of the scaffold design and its fixation system in different clinical scenarios.

Authors

Institutions

Publication Details

Journal
Frontiers in Bioengineering and Biotechnology
Published
2025-09-01
DOI
https://doi.org/10.3389/fbioe.2025.1535756
Primary Topic
Bone fractures and treatments
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

In silico testing of a multimaterial scaffold for mandibular reconstruction

Renato Natal Jorge, Sara Checa, Bruno Areias, Vincenzo Orassi et al.
Frontiers in Bioengineering and Biotechnology
Bone fractures and treatments
article

In silico testing of a multimaterial scaffold for mandibular reconstruction

Renato Natal Jorge, Sara Checa, Bruno Areias, Vincenzo Orassi, Carsten Rendenbach, Marco Parente, Nilza Ramião, João Correia, Pedro Rebolo
article en

Abstract

No failure was predicted in the fixation devices for any of the configurations investigated. The PLA fixation device induced higher strains within the healing region than the titanium fixation device. Differences in scaffold architecture did not influence the strain levels within the healing region. Changes in the scaffold material distribution led to considerable differences in the mechanical strains within the scaffold pores. The multimaterial scaffold induced higher strains within the healing region than the only hydrogel scaffold, which might be beneficial to promote bone healing in the defect. Thus, a multimaterial scaffold seems to be able to provide a more suitable biomechanical environment to support bone regeneration, especially in large segmental defects. Future studies should focus on the mechanobiological optimization of the scaffold design and its fixation system in different clinical scenarios.

Frontiers in Bioengineering and BiotechnologyVol. 13
Universität Hamburg (DE), Universidade do Porto (PT), Institute of Mechanical Engineering and Industrial Mangement (PT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Hamburg University of Technology (DE)
Universidade de Aveiro, European Commission, Horizon 2020 Framework Programme, Horizon 2020
Openalex Percentile: Top 69%
Bone fractures and treatments
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.