APOE genotype-dependent differences in human astrocytic energy metabolism
Our study provides evidence for <i>APOE</i> genotype-dependent effects on astrocyte energy metabolism and highlights alterations in the bioenergetic processes of the brain as important pathomechanisms in AD.
Authors
- Ruslan Rust (ORCID: https://orcid.org/0000-0003-3376-3453)
- L. Felipe Barros (ORCID: https://orcid.org/0000-0002-6623-4833)
- Kathrin J. Zürcher
- Maik Krüger
- Bruno Weber (ORCID: https://orcid.org/0000-0002-9089-0689)
- Christian Tackenberg (ORCID: https://orcid.org/0000-0002-0019-3055)
- R. Weber (ORCID: https://orcid.org/0000-0002-6912-3573)
- Iván Ruminot (ORCID: https://orcid.org/0000-0002-3985-384X)
- Luca Ravotto (ORCID: https://orcid.org/0000-0002-0431-9866)
- Sherida M. de Leeuw (ORCID: https://orcid.org/0000-0002-9863-7127)
- Vanessa Budny
- Chantal Bodenmann
Institutions
- University of Southern California (US)
- University of Zurich (CH)
- San Sebastián University (CL)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Centro de Estudios Científicos (CL)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fncel.2025.1603657
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universität Zürich
- Agencia Nacional de Investigación y Desarrollo
- Neuroscience Center Zurich, University of Zurich