COMPARISON OF MIDAZOLAM-KETAMINE COMBINATION WITH ORAL MIDAZOLAM IN CHILDREN AGED FROM 1 TO 6 YEARS

In paediatric anaesthesia, an important and common issue that has been reported is preoperative anxiety. It happens especially in children who are between 1 to 6 years old. Children express this anxiety in terms of crying restlessness, not cooperating in the start of anaesthesia, and not leaving their parents. Due to this, the need for more anaesthesia arises which can create behavioural problems after the surgery. In order to reduce anxiety in children before any treatment, pharmacologic premedication is used. Midazolam is one common medicine which is used for this purpose. It is a short-acting benzodiazepine which has an anxiolytic effect (reduces anxiety quickly). Combination regimens, such as Ketamine (an MNDW receptor antagonist), are used by doctors to make the sedation more effective.