H3K18la Facilitates TRA2A-Mediated Alternative Splicing of STIL, Suppressing Ferroptosis and Cisplatin Treatment Sensitivity in Ovarian Cancer
This study uncovers for the first time a novel mechanism by which OC cells evade ferroptosis via an H3K18la-modified TRA2A-STIL signaling axis, thereby establishing a promising new therapeutic target for OC treatment.
Authors
- Mingyang Gao (ORCID: https://orcid.org/0000-0002-8304-7909)
- Shiming Wang (ORCID: https://orcid.org/0000-0003-4886-2542)
- Yuexin Yu (ORCID: https://orcid.org/0000-0003-2804-6417)
- Tianliang Wang (ORCID: https://orcid.org/0000-0003-4468-7820)
- Zheng‐Ming Huang (ORCID: https://orcid.org/0009-0005-1800-0222)
Institutions
- Central Hospital Affiliated to Shenyang Medical College (CN)
- Xinhui People's Hospital (CN)
- General Hospital of Shenyang Military Region (CN)
- Jiangmen Central Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-09-01
- DOI
- https://doi.org/10.4143/crt.2025.752
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00