Ghrelin’s potential as a therapeutic target for chronic inflammatory diseases: evidence from human endometrial stromal cells
Ghrelin can exert its effects through its receptor GHSR. Meanwhile, Ghrelin stimulates cell growth without causing decrease in viability; it has cell protective effect by regulating inflammation at the molecular level by balancing the release of some key pro-inflammatory cytokines. This study discovered and validated the anti-inflammatory effect of Ghrelin in patients with endometriosis. Thus, the data presented open a potential use of Ghrelin as therapy for chronic inflammation-related disorders as endometriosis.
Authors
- Shizhao Zhou (ORCID: https://orcid.org/0000-0001-8456-6260)
- JingJing Lv (ORCID: https://orcid.org/0000-0003-3455-5314)
- Yingying Wei (ORCID: https://orcid.org/0000-0003-2177-2301)
- Wenhui Dong
- Jia Fan (ORCID: https://orcid.org/0000-0003-3487-2328)
- Tingting Liang (ORCID: https://orcid.org/0000-0003-1370-3672)
- Shiping Yu (ORCID: https://orcid.org/0000-0002-1783-1674)
- Hongkai Mu
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Luliang University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fendo.2025.1587490
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Shanxi Province
- National Natural Science Foundation of China
- Shanxi Scholarship Council of China
- Shanxi Medical University