MINDY1 Induces PD-L1 Deubiquitination to Promote Immune Escape in Hepatocellular Carcinoma by the Wnt/β-Catenin Pathway
MINDY1 promotes PD-L1 deubiquitination and inhibits CD8<sup>+</sup> T cell activation by stimulating the Wnt/β-catenin pathway, consequently promoting HCC tumor immune escape.
Authors
- Xiao Ma (ORCID: https://orcid.org/0000-0001-8370-4131)
- Chunyan Tian (ORCID: https://orcid.org/0000-0003-1589-293X)
- Xingchao Song (ORCID: https://orcid.org/0000-0003-2972-6713)
- Qiuyu Song
- Aijing Xu
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.067638
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05