Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients
Our findings reveal a significant remodeling of the gut microbiota-metabolome axis in fracture patients with low bone mass, highlighting a context-dependent, potentially pathological role for the typically beneficial species <i>L. eligens</i>. These distinct microbial and metabolic signatures suggest potential mechanistic insights into the gut-bone axis and represent promising, non-invasive biomarkers for assessing skeletal health.
Authors
- Bin Wu (ORCID: https://orcid.org/0000-0002-5247-7332)
- Yejun Zha (ORCID: https://orcid.org/0000-0001-7124-2128)
- Pengli Han
- M.K.W. Li (ORCID: https://orcid.org/0009-0009-3632-1838)
- Xian Zhao (ORCID: https://orcid.org/0000-0002-1523-4534)
- Cheng Cheng (ORCID: https://orcid.org/0000-0002-3457-1624)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-7990-4947)
- Zhongyu Wang (ORCID: https://orcid.org/0000-0001-8636-8305)
- Ruochen Cao (ORCID: https://orcid.org/0000-0002-0312-8355)
- Hongkai Lian (ORCID: https://orcid.org/0000-0002-6630-3077)
Institutions
- Qingdao University (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Zhengzhou University (CN)
- Qingdao Municipal Hospital (CN)
- Zhengzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fmolb.2025.1646361
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Capital Medical University