Effects of parthenolide on amino acid metabolism and oxidative stress in lung adenocarcinoma based on quantitative proteomic analysis, targeted amino acid metabolomics, network pharmacology, and experimental validation
PTL affects proliferation, amino acid metabolism, and oxidative stress levels of LUAD cells via targeting GCTG. Therefore, our study provides new insights into the prevention and treatment of LUAD with PTL, which may lay the foundation for future research directions.
Authors
- Shuang Shen (ORCID: https://orcid.org/0000-0002-0845-2533)
- Ji-Ye Liu (ORCID: https://orcid.org/0009-0000-9368-7099)
- Jie Liu (ORCID: https://orcid.org/0000-0002-7441-2417)
- Jiachun Li (ORCID: https://orcid.org/0000-0002-2994-0800)
Institutions
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fonc.2025.1642866
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shengjing Hospital