Identifying aging-related biomarkers in adipose tissue using integrative bioinformatics and machine-learning approaches: discovery of ELN, MXD1, and FGF21 as key genes
This study identified three DEARGs (ELN, MXD1, and FGF21) as potential biomarkers of adipose tissue aging, suggesting their role in organismal aging and age-related disease pathways.
Authors
- Shunli Rui (ORCID: https://orcid.org/0000-0002-1251-6747)
- Bo Deng (ORCID: https://orcid.org/0000-0002-4679-1165)
- Dawei Tang (ORCID: https://orcid.org/0000-0002-8914-7038)
- Xiaoyan Jiang (ORCID: https://orcid.org/0000-0002-1968-6810)
- Fugang Xiao (ORCID: https://orcid.org/0000-0003-3024-6987)
- Hongyan Wang (ORCID: https://orcid.org/0009-0000-3994-5456)
- Yan Chen (ORCID: https://orcid.org/0000-0003-3516-9546)
- Gangyi Yang (ORCID: https://orcid.org/0000-0002-6458-6747)
- Xi Cheng (ORCID: https://orcid.org/0000-0002-0009-8189)
- Xin Xie (ORCID: https://orcid.org/0000-0001-8472-6498)
- Yanzhong Wang (ORCID: https://orcid.org/0000-0003-1390-9099)
- Wuquan Deng (ORCID: https://orcid.org/0000-0002-5450-9713)
- Chenghu Huang (ORCID: https://orcid.org/0009-0006-9630-6750)
Institutions
- King's College London (GB)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- People's Hospital of Bishan District (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fendo.2025.1638343
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Major Project