Molecular mechanism of LncRNA MALAT1 in regulating hepatocellular carcinoma progression via the miR-383-5p/PRKAG1 axis and its role in the tumor immune microenvironment
This study elucidates the oncogenic role of the MALAT1/miR-383-5p/PRKAG1 axis in HCC, demonstrating that PRKAG1 promotes tumor progression by regulating cell proliferation, the immune microenvironment, and key signaling pathways. These findings provide potential novel targets for HCC prognosis assessment and targeted therapy.
Authors
- Shan Lu (ORCID: https://orcid.org/0000-0002-8262-8779)
- Anni Wang (ORCID: https://orcid.org/0000-0003-3109-7514)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-5854-2468)
- Shujun J. Zhang (ORCID: https://orcid.org/0000-0001-6139-6887)
- Mingze Li
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3389/fonc.2025.1613596
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94