ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs
These findings extend the immune-regulatory role of the ECM to include regulatory T cells and identify potential new therapeutic targets for high-grade breast cancers. Moreover, they highlight ECM3 as a potential biomarker of resistance to PD-1/PD-L1 immune checkpoint blockade (ICB), suggesting that ECM3⁺ patients may benefit from alternative checkpoint inhibitor therapies beyond PD-1/PD-L1.
Authors
- Paolo Verderio (ORCID: https://orcid.org/0000-0002-9231-1281)
- Vera Cappelletti (ORCID: https://orcid.org/0000-0002-9709-0676)
- Giovanna Talarico (ORCID: https://orcid.org/0000-0001-5051-6468)
- Laura Botti (ORCID: https://orcid.org/0000-0001-9032-6810)
- P Pratesi (ORCID: https://orcid.org/0009-0005-1215-9849)
- Sabina Sangaletti (ORCID: https://orcid.org/0000-0001-7047-287X)
- Serenella M. Pupa (ORCID: https://orcid.org/0000-0002-4592-6830)
- Mara Lecchi (ORCID: https://orcid.org/0000-0002-0405-9339)
- Annamaria Piva (ORCID: https://orcid.org/0000-0003-2225-5787)
- Massimo Costanza (ORCID: https://orcid.org/0000-0002-1673-8574)
- Paola Portararo (ORCID: https://orcid.org/0000-0003-0085-6901)
- Massimo Di Nicola (ORCID: https://orcid.org/0000-0002-7689-5774)
- Francesco Bertolini (ORCID: https://orcid.org/0000-0001-5660-3255)
- Anna Zanichelli (ORCID: https://orcid.org/0009-0009-1695-5024)
- Valeria Cancila (ORCID: https://orcid.org/0000-0002-9502-1191)
- Mario P. Colombo (ORCID: https://orcid.org/0000-0003-0042-7955)
- Claudia Chiodoni (ORCID: https://orcid.org/0000-0002-7644-9969)
- Claudio Tripodo (ORCID: https://orcid.org/0000-0002-0821-6231)
Institutions
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- European Institute of Oncology (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13046-025-03518-0
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro