Integrated metabolomics and the microbiome reveal the compatibility mechanism of the Suxiao Jiuxin pill in the treatment of stable coronary artery disease
This study is the first to demonstrate a link between SJP treatment in SCAD patients and improved lipid metabolism. Borneol enriches A. muciniphila in a dose-dependent manner, thereby regulating host lipid metabolism and facilitating the absorption of the active components of Chuanxiong Rhizoma into the blood.
Authors
- Gaosong Wu (ORCID: https://orcid.org/0000-0002-7548-1588)
- Yuanyuan Zeng (ORCID: https://orcid.org/0000-0001-7621-3342)
- Xiaoxu Shen (ORCID: https://orcid.org/0000-0003-3729-8691)
- Jingyu Liao
- Houkai Li (ORCID: https://orcid.org/0000-0003-2846-7895)
- Yuhao Zhang (ORCID: https://orcid.org/0000-0001-9081-3125)
- Weidong Zhang (ORCID: https://orcid.org/0000-0002-7384-2490)
- Jingjing Xu (ORCID: https://orcid.org/0000-0001-6672-7630)
- Wanqi Le
Institutions
- Second Military Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13020-025-01198-8
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China