Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1
STS ameliorated OA by activating SIRT1 and inhibiting NF-κB p65-driven inflammation and ferroptosis, indicating its potential therapeutic application in OA patients.
Authors
- Xinxin Jin (ORCID: https://orcid.org/0000-0002-6701-9430)
- Zixuan Qin
- Xiao Ma (ORCID: https://orcid.org/0000-0001-8370-4131)
- Xiaochen Sun (ORCID: https://orcid.org/0000-0002-2297-1217)
- Xīn Gào (ORCID: https://orcid.org/0000-0003-0108-6961)
- Mao Xu (ORCID: https://orcid.org/0000-0002-1322-5482)
- Hongzhi Sun (ORCID: https://orcid.org/0000-0002-5434-8112)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Huazhong University of Science and Technology (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1186/s13020-025-01166-2
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province
- Natural Science Foundation of Shaanxi Province
- Nanjing University
- Fundamental Research Funds for the Central Universities
- Nanhu Scholars Program for Young Scholars of Xinyang Normal University