Predictive value of MHC-related genes in cervical cancer: implications for immunotherapy and prognostic nomogram development
We propose a robust MHCRG-based gene signature, validated through both bioinformatic analyses and in vitro functional experiments. These findings offer translational potential for improving risk stratification and guiding immunotherapy in CC patients.
Authors
- Ai‐Min Ren (ORCID: https://orcid.org/0000-0002-9192-1483)
- Xiao Xu (ORCID: https://orcid.org/0000-0002-2761-2811)
- Meili Xi (ORCID: https://orcid.org/0000-0001-7021-1901)
- Xiaoqing Wang (ORCID: https://orcid.org/0000-0001-7036-7930)
- Jiarong Zhang (ORCID: https://orcid.org/0000-0002-6627-9169)
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Shanghai Xuhui Central Hospital (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1007/s12672-025-03460-9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China