Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses
Our findings highlight a subset of circulating inflammatory proteins that are likely causal in asthma pathogenesis and may serve as promising targets for therapeutic intervention. These results offer novel insights into the immunological mechanisms underlying asthma and support the utility of genetic causal inference in target prioritization.
Authors
- Quan Wei (ORCID: https://orcid.org/0000-0002-0541-905X)
- Kun Yan (ORCID: https://orcid.org/0000-0001-5779-6394)
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-8036-698X)
- Yinglei Miao (ORCID: https://orcid.org/0000-0001-8193-5198)
- Gaobo Yu
- Haihua Chen (ORCID: https://orcid.org/0000-0003-0208-5346)
- Praise Audax Rukonge
Institutions
- Xuzhou Medical College (CN)
- Jiangyin People's Hospital (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
Publication Details
- Journal
- Journal of Asthma
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1080/02770903.2025.2555292
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00