Dual therapy with vildagliptin and sacubitril/valsartan alleviates portal hypertension and inhibits soluble epoxide hydrolase in cirrhotic rats

Combined DPP4-I with ARNI therapy ameliorates PH and fibrosis <i>via</i> sEH suppression and EET restoration, offering a promising treatment strategy for cirrhosis-related PH.

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Publication Details

Journal
World Journal of Gastroenterology
Published
2025-09-01
DOI
https://doi.org/10.3748/wjg.v31.i33.109562
Primary Topic
Eicosanoids and Hypertension Pharmacology
Type
article
Field-Weighted Citation Impact
0.00
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article

Dual therapy with vildagliptin and sacubitril/valsartan alleviates portal hypertension and inhibits soluble epoxide hydrolase in cirrhotic rats

Junichi Hanatani, Hitoshi Yoshiji, Koh Kitagawa, Tadashi Namisaki et al.
World Journal of Gastroenterology
Eicosanoids and Hypertension Pharmacology
article

Dual therapy with vildagliptin and sacubitril/valsartan alleviates portal hypertension and inhibits soluble epoxide hydrolase in cirrhotic rats

Junichi Hanatani, Hitoshi Yoshiji, Koh Kitagawa, Tadashi Namisaki, Shohei Asada, Naoki Nishimura, Akihiko Shibamoto, Norihisa Nishimura, Kosuke Kaji, Masafumi Oyama, Shinya Sato, Tatsuya Nakatani, Yuki Tsuji
article en

Abstract

Combined DPP4-I with ARNI therapy ameliorates PH and fibrosis <i>via</i> sEH suppression and EET restoration, offering a promising treatment strategy for cirrhosis-related PH.

World Journal of GastroenterologyVol. 31(33)
Nara Medical University (JP)
Openalex Percentile: Top 78%
Eicosanoids and Hypertension Pharmacology
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