Exosomes derived from human umbilical cord mesenchymal stem cells attenuate hepatic ischaemia-reperfusion injury <i>via</i> the let-7i-5p/Faslg axis
Our findings indicate that hucMSC-exos alleviate HIRI by inhibiting apoptosis. We demonstrated that hucMSC-exos target apoptosis in L02 cells and mediate the let-7i-5p/factor-related apoptosis ligand pathway, thereby ameliorating HIRI. This study provides new insights into the role of hucMSC-exos in hepatocyte apoptosis and highlights the potential of hucMSC-exos as a therapeutic strategy for HIRI.
Authors
- Min He (ORCID: https://orcid.org/0000-0003-0361-8984)
- Hanfei Huang (ORCID: https://orcid.org/0000-0002-0852-9596)
- Yaping Xiang (ORCID: https://orcid.org/0000-0002-5591-8690)
- Jia-Jiao Luo
- Congwen Bian
- Yuting Yang (ORCID: https://orcid.org/0000-0002-1064-688X)
- Rui Yu (ORCID: https://orcid.org/0000-0003-2330-6937)
- Zhong Zeng (ORCID: https://orcid.org/0000-0001-9264-4871)
- Yao Gao (ORCID: https://orcid.org/0000-0003-1957-7232)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.3748/wjg.v31.i33.108653
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00