Association of metformin treatment with changes in metal dynamics in individuals with type 2 diabetes
Metformin use was associated with reduced serum levels of copper and iron, as well as with increased serum zinc levels. These changes in metal dynamics may be related to the pharmacological effects of this widely administered drug.
Authors
- Hayato Fukumitsu
- Natsu Otowa‐Suematsu (ORCID: https://orcid.org/0000-0003-4982-0336)
- Yushi Hirota (ORCID: https://orcid.org/0000-0002-3035-4155)
- Wataru Ogawa (ORCID: https://orcid.org/0000-0002-0432-4366)
- Y. Katsura
- Masayasu Nishisaka
- Kenji Sugawara (ORCID: https://orcid.org/0000-0002-6549-7885)
- Yuko Okada (ORCID: https://orcid.org/0000-0001-6964-5147)
- Tomoko Yamada (ORCID: https://orcid.org/0000-0001-6023-4069)
- Kazuhiko SAKAGUCHI
- Yasuko Morita
Institutions
- Diabetes Australia (AU)
- Kobe University (JP)
Publication Details
- Journal
- BMJ Open Diabetes Research & Care
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1136/bmjdrc-2025-005255
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- Eli Lilly and Company
- Sanofi
- Abbott Japan
- Novo Nordisk
- Otsuka Pharmaceutical
- Manpei Suzuki Diabetes Foundation
- Novartis Pharma
- Eli Lilly Japan
- Novo Nordisk Pharma
- Sanofi K.K.
- Medtronic Japan
- Japan Society for the Promotion of Science