Impact of stopping Tenofovir disoproxil fumarate at various times on elevated postpartum ALT levels and breastfeeding in pregnant women with chronic hepatitis B: a prospective observational cohort study
When TDF is used to prevent MTCT of HBV, withdrawal timing did not significantly affect overall ALT elevation patterns. However, early TDF withdrawal at delivery was associated with higher breastfeeding rates, and mothers with ALT levels ≥ 23 U/L at delivery may benefit from extended postpartum antiviral therapy.
Authors
- Jie Jin (ORCID: https://orcid.org/0000-0002-8166-9915)
- Jinfeng Shi
- Yi Jiang (ORCID: https://orcid.org/0000-0002-6300-1794)
- Yinghua Li (ORCID: https://orcid.org/0000-0003-0152-4343)
- Zhiyuan Ma (ORCID: https://orcid.org/0000-0002-8118-7545)
- Siying Li (ORCID: https://orcid.org/0000-0001-6906-8394)
- Xiaoxian Jiang
Institutions
- Westlake University (CN)
- Hangzhou Women’s Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12884-025-08078-x
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00