LAPTM4B as a key regulator in the copper-induced endoplasmic reticulum–lysosome interplay disorder in duck liver and the protective role of baicalin
In summary, the present study demonstrates that Cu exposure disrupts ER-lysosomal crosstalk in duck liver, leading to ER-lysosomal damage and subsequent hepatocyte injury. In contrast, Ba alleviates this injury by selectively targeting LAPTM4B, ultimately attenuating Cu-induced hepatotoxicity.
Authors
- Xueyan Dai (ORCID: https://orcid.org/0000-0003-0971-4010)
- Hongyu Shang (ORCID: https://orcid.org/0000-0002-7125-8477)
- Chenghong Xing
- Huabin Cao
- Jing Chen (ORCID: https://orcid.org/0000-0002-1341-9447)
- Fan Yang (ORCID: https://orcid.org/0000-0003-4124-8419)
- Guoliang Hu (ORCID: https://orcid.org/0000-0003-1806-1517)
- Hanyue Li (ORCID: https://orcid.org/0009-0001-7281-0120)
- Mingwen Hu
- Xiaona Gao
Institutions
- Jiangxi Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s40104-025-01255-0
- Citations
- 17
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 23.02
Funders
- National Natural Science Foundation of China