Repeat cell-free DNA screening after initial false-positive results and term placental analysis for confined mosaicism: a prospective cohort study
High-risk r-cfDNA is not a sensitive predictor of CPM, though high mosaic ratios are associated with adverse obstetric outcomes. An alternative explanation for false-positive cfDNA besides CPM may be low fetal fraction, particularly in the context of high maternal BMI.
Authors
- Tristan Hardy (ORCID: https://orcid.org/0000-0002-5878-0340)
- Andrew McLennan (ORCID: https://orcid.org/0000-0002-8979-4534)
- Daniel L. Rolnik (ORCID: https://orcid.org/0000-0002-2263-3592)
- Shavi Fernando (ORCID: https://orcid.org/0000-0001-9160-0084)
- Emma Brown
- Yvette C. Raymond (ORCID: https://orcid.org/0000-0001-8197-7996)
- Ben W. Mol (ORCID: https://orcid.org/0000-0001-8337-550X)
- K. Levin (ORCID: https://orcid.org/0000-0002-6573-2590)
- Melody A. Menezes (ORCID: https://orcid.org/0000-0003-3854-0224)
Institutions
- The University of Sydney (AU)
- The University of Melbourne (AU)
- University of Aberdeen (GB)
- Monash Medical Centre (AU)
- Australian Federation of Graduate Women New South Wales (AU)
- Victorian Clinical Genetics Services (AU)
- Monash Health (AU)
- Monash IVF (AU)
- Monash University (AU)
Publication Details
- Journal
- Archives of Gynecology and Obstetrics
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1007/s00404-025-08162-9
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Norman Beischer Medical Research Foundation
- Monash University