Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma
A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [<sup>18</sup>F]-metafluorobenzylguanidine (mFBG), [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [<sup>123</sup>I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [<sup>18</sup>F]-mFBG-PET, and revealed insights into tumour heterogeneity.
Authors
- Fredrik Hedeer
- Jenny Oddstig (ORCID: https://orcid.org/0000-0002-7588-5873)
- Páll Hallgrimson
- Katarina Fagher
Institutions
- Lund University (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s41824-025-00267-3
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lunds Universitet
- Rigshospitalet