Subcortical brain volume variations in autistic individuals across the lifespan
Autistic participants and neurotypical controls exhibit distinct, age-related volumetric patterns across key subcortical brain regions. Enlargement of the cerebral ventricles and their inverse structural relationships with neighboring structures in later life may indicate atrophic processes beginning in middle adulthood in ASD. These findings highlight the need to further investigate mechanisms of atypical brain aging in ASD and consider these subcortical brain regions as potential biomarkers of neurodegeneration and intervention targets across the adult lifespan.
Authors
- Kathryn E. Unruh (ORCID: https://orcid.org/0000-0001-6745-5550)
- Carolina R. Cuomo
- Bikram Karmakar (ORCID: https://orcid.org/0000-0002-9336-5062)
- Matthew W. Mosconi (ORCID: https://orcid.org/0000-0002-1981-6777)
- Walker S. McKinney (ORCID: https://orcid.org/0000-0001-5281-3749)
- Stormi L. Pulver
- Zheng Wang (ORCID: https://orcid.org/0000-0003-2265-0891)
- Jingying Wang (ORCID: https://orcid.org/0000-0002-9766-2769)
- Stephen A. Coombes (ORCID: https://orcid.org/0000-0001-8616-5364)
- Cliff R. Stevens
- Danielle Christensen
- Young Seon Shin
- Ann-Marie Orlando
- Hanna M. Gemmell (ORCID: https://orcid.org/0009-0002-3439-3888)
- Tyler Dentry
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Kansas (US)
- Emory University (US)
- University of Florida (US)
- Florida College (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- Molecular Autism
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s13229-025-00673-1
- Citations
- 3
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- University of Florida
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke