Analysis and Comparison of Gamma Oscillation by Meso-Scale Model of Human Cerebral Cortex

Anatomical differences in the cortex between people with Major Depressive Disorder (MDD) and healthy subjects have been previously reported, and there are also functional differences of brain gamma-band activity between them. However, the effects of the anatomical differences on brain activity are still unknown. Gamma oscillation is considered as a region specific activity. As such, we constructed a personalized meso-scale brain simulation with the neural mass model that has biologically plausible parameters. Then we analyzed the differences of the synchronization of gamma-band neural activity in the cortex caused by the differences in the gray matter structure. We also generated the EEG signal from simulated neural activity and examined its appropriateness for simulating EEG values by comparing the generated signal with the simulation from the previous multi-compartment model. Finally, the simulated signals were compared between subjects with MDD and those of a healthy participant.