Prophylactic efficacy of cannabidiol and sodium nitroprusside in a ketamine-model of schizophrenia: sex-dependent effects on positive-like and cognitive impairments
This study provides the first preclinical evidence of sex-dependent prophylactic efficacy of CBD-SNP in a schizophrenia model, suggesting a promising therapeutic strategy.
Authors
- J.E.P. Santos (ORCID: https://orcid.org/0000-0003-3403-1465)
- João Abrão (ORCID: https://orcid.org/0000-0003-1810-5575)
- Vanessa C. Abı́lio
- Isabella Caroline da Silva Dias (ORCID: https://orcid.org/0000-0001-9915-6862)
- Matheus Teixeira Rossignoli (ORCID: https://orcid.org/0000-0002-0522-2337)
- Lezgin Dursun (ORCID: https://orcid.org/0000-0003-2555-4045)
- João Pereira Leite (ORCID: https://orcid.org/0000-0003-0558-3519)
- José Alexandre S. Crippa (ORCID: https://orcid.org/0000-0001-9520-6746)
- Rafael G. dos Santos (ORCID: https://orcid.org/0000-0003-2388-4745)
- Antônio Waldo Zuardi (ORCID: https://orcid.org/0000-0002-0479-6670)
- Rafael Naime Ruggiero (ORCID: https://orcid.org/0000-0002-4712-6853)
- Serdar Dursun (ORCID: https://orcid.org/0000-0001-9943-851X)
- Jaime E. C. Hallak (ORCID: https://orcid.org/0000-0002-8784-0189)
- DA Prado
- Gleiciane Gontijo Avelar
Institutions
- Federal Institute of São Paulo (BR)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Universidade de Ribeirão Preto (BR)
- Pontifícia Universidade Católica de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- National Institute for Nanotechnology (CA)
- Clinics Hospital of Ribeirão Preto (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Brazilian Journal of Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.47626/1516-4446-2025-4301
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Alberta
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo