Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation
These results suggest that YPG can activate the SIRT1/Nrf2/HO-1 signaling pathway by regulating the expression level of SIRT1 to regulating the acetylated expression level of Nrf2, to inhibit the senescence of ASMCs, leading to the treatment of asthma.
Authors
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0002-2832-0597)
- Deling Wu (ORCID: https://orcid.org/0000-0001-6027-0625)
- Lingyu Pan
- Dezhi Yuan
- Yanquan Han (ORCID: https://orcid.org/0000-0001-7655-397X)
- Yongzhong Wang (ORCID: https://orcid.org/0000-0001-6813-3289)
- Bangfu He
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-08-31
- DOI
- https://doi.org/10.1186/s12931-025-03345-z
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00