Effects of dietary interventions on senescence processes in cardiometabolic diseases

Cell aging processes (senescence) in the development of cardiometabolic diseases, including type 2 diabetes mellitus (T2DM), remain poorly understood. Research on the effect of dietary interventions on cell aging is of undoubted importance for scientific and practical medicine. The purpose of the review was to assess the effect of dietary interventions on senescence processes in cardiometabolic diseases. Literature data were collected and analyzed using the RINTS, Pubmed, and Google Scholar databases using the keywords «senescence», «chronic noncommunicable diseases», «systemic chronic inflammation», «T2DM». Results. Senescence has been shown to be a key factor in aging and contributes to tissue dysfunction and the development of many diseases. Dietary interventions with anti-inflammatory and antioxidant effects may become an important additional option for maintaining metabolic health during cellular aging and are of great interest in terms of prevention and management of chronic non-communicable diseases. Restriction of caloric intake, reduction of simple carbohydrates, inclusion of foods enriched with vitamins and minerals, polyphenolic compounds, and other strategies may provide additional information to deepen our understanding of the potential role of senescence in the development and progression of nutrition-related diseases. Conclusions. The search for new strategies for dietary intervention. Cells that affect senescence processes play a key role in the development and progression of cardiometabolic diseases, which opens up broad prospects for influencing senescent cells, providing support for dietary interventions to achieve healthy longevity.