The importance of liver detoxication function and the severity of endotoxinemia in the formation and implementation of central dysregulatory effects on body temperature

At the present stage of the development of medical science, no one doubts that dysregulation underlies many pathological processes. Endotoxinemia serves as a key factor in the pathogenesis of these processes, and its severity is largely determined by the state of detoxication function of the liver. The aim of this study was to clarify the importance of liver detoxication function and the severity of endotoxinemia in the formation and manifestation of central dysregulatory effects on body temperature. Experiments conducted on rats and rabbits revealed that the direction of changes in body temperature, as well as the nature of changes in catabolic and anabolic processes of the body under the action of E. сoli endotoxin, depend on the state of the liver detoxication function, the severity of endotoxemia, and the accompanying neurotransmitter, hormonal, and humoral imbalances, ensuring the interaction of various organs and systems. It has been shown that, depending on the state of liver detoxification capacity, the same dose of endotoxin can lead to an increase in body temperature, have no effect on it, or cause hypothermia. Additionally, under conditions of bacterial endotoxinemia, accompanied by elevated body temperature and increased liver arginase activity, the level of the amino acid arginine in blood plasma decreases. Furthermore, the liver arginase deficiency in conditions of endotoxin fever prevents the activation of liver detoxication function and the increase in body temperature. It was established that the ambiguous direction and nature of the revealed changes in the processes are largely due to changes in the properties of cerebral neurons, particularly within the cholinergic and adrenoreactive systems of the hypothalamic region of the brain. These changes are caused by the intake of arginine from blood plasma and cerebrospinal fluid into the structures of the hypothalamus. The findings indicate that insufficient liver detoxication function and the severity of endotoxinemia are significant factors in the formation and implementation of central dysregulatory effects on body temperature.